9/5/2023 0 Comments Brain neuron![]() ![]() ![]() In the earlier stage, they observed a central core of amyloid plaque surrounded by a type of immune cell in the brain called microglia, which are known to play a role in Alzheimer’s. The researchers used their approach to study brain tissue from the Alzheimer’s mouse model at two different stages of the disease and at high spatial resolution. The technique, called STARmap PLUS, is the first to simultaneously map gene expression of individual cells and their location, as well as the spatial distribution of specific proteins in intact tissue samples. The team used a new method they developed to reveal how brain cells located near these proteins change as the disease progresses in a mouse model of Alzheimer’s. Researchers don’t know how these protein deposits are related to the other major hallmark of the disease: the death of neurons in the brain.Ī study by scientists at the Broad Institute of MIT and Harvard published today in Nature Neuroscience hints at some answers to this question. The following press release was issued today by the Broad Institute of MIT and Harvard.Ī common sign of Alzheimer’s disease is the excessive buildup of two types of protein in the brain: tangles of tau proteins that accumulate inside cells, and amyloid-β proteins that form plaques outside the cells. ![]()
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